Assay Detail
Binding
CHEMBL4825839
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human CA12 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.07 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 8.42 |
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 8.35 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL4848020 | — | — | 1 | 7.68 |
| CHEMBL4850250 | — | — | 1 | 7.68 |
| CHEMBL4876361 | — | — | 1 | 7.43 |
| CHEMBL4862704 | — | — | 1 | 7.36 |
| CHEMBL4851043 | — | — | 1 | 7.33 |
| CHEMBL4855176 | — | — | 1 | 7.32 |
| CHEMBL4876551 | — | — | 1 | 7.23 |
| CHEMBL4875448 | — | — | 1 | 7.22 |
| CHEMBL4864527 | — | — | 1 | 7.22 |
| CHEMBL4870207 | — | — | 1 | 7.15 |
| CHEMBL4869520 | — | — | 1 | 7.14 |
| CHEMBL4865065 | — | — | 1 | 7.10 |
| CHEMBL4860722 | — | — | 1 | 7.09 |
| CHEMBL4856565 | — | — | 1 | 7.07 |
| CHEMBL4849362 | — | — | 1 | 7.05 |
| CHEMBL4867955 | — | — | 1 | 7.03 |
| CHEMBL4855598 | — | — | 1 | 6.64 |
| CHEMBL4860586 | — | — | 1 | 6.54 |
| CHEMBL4857705 | — | — | 1 | 6.50 |
| CHEMBL4878810 | — | — | 1 | 6.47 |
| CHEMBL4851050 | — | — | 1 | 6.30 |
| CHEMBL4856821 | — | — | 1 | 6.25 |
| CHEMBL4877756 | — | — | 1 | 6.06 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL750 | ZONISAMIDE | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL1615281 | SLC-0111 | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL4848020 | — | Ki | = | 20.8 | nM | 7.68 |
| CHEMBL4850250 | — | Ki | = | 20.7 | nM | 7.68 |
| CHEMBL4876361 | — | Ki | = | 36.7 | nM | 7.43 |
| CHEMBL4862704 | — | Ki | = | 43.6 | nM | 7.36 |
| CHEMBL4851043 | — | Ki | = | 46.3 | nM | 7.33 |
| CHEMBL4855176 | — | Ki | = | 47.8 | nM | 7.32 |
| CHEMBL4876551 | — | Ki | = | 58.4 | nM | 7.23 |
| CHEMBL4875448 | — | Ki | = | 60.7 | nM | 7.22 |
| CHEMBL4864527 | — | Ki | = | 60.2 | nM | 7.22 |
| CHEMBL4870207 | — | Ki | = | 70.4 | nM | 7.15 |
| CHEMBL4869520 | — | Ki | = | 72.9 | nM | 7.14 |
| CHEMBL4865065 | — | Ki | = | 78.9 | nM | 7.10 |
| CHEMBL4860722 | — | Ki | = | 81.6 | nM | 7.09 |
| CHEMBL4856565 | — | Ki | = | 85.3 | nM | 7.07 |
| CHEMBL4849362 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL4867955 | — | Ki | = | 94.1 | nM | 7.03 |
| CHEMBL4855598 | — | Ki | = | 227.5 | nM | 6.64 |
| CHEMBL4860586 | — | Ki | = | 287.8 | nM | 6.54 |
| CHEMBL4857705 | — | Ki | = | 316.2 | nM | 6.50 |
| CHEMBL4878810 | — | Ki | = | 339.8 | nM | 6.47 |
| CHEMBL4851050 | — | Ki | = | 505.9 | nM | 6.30 |
| CHEMBL4856821 | — | Ki | = | 561.9 | nM | 6.25 |
| CHEMBL4877756 | — | Ki | = | 863.2 | nM | 6.06 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 11000.0 | nM | 4.96 |