Assay Detail
Binding
CHEMBL4825980
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of paclitaxel stimulated- P-gp ATPase activity (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.97 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4594298 | ENCEQUIDAR | 3.0 | 1 | 9.22 |
| CHEMBL396298 | ELACRIDAR | 2.0 | 1 | 8.31 |
| CHEMBL348475 | TARIQUIDAR | 3.0 | 1 | 7.49 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4594298 | ENCEQUIDAR | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL396298 | ELACRIDAR | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL348475 | TARIQUIDAR | IC50 | = | 32.7 | nM | 7.49 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 141.3 | nM | 6.85 |