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Assay Detail

CHEMBL4826257

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Competitive inhibition of Plasmodium falciparum HGPRT by Morrison method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Plasmodium falciparum
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

<i>Helicobacter pylori</i> Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase-A Putative Target for Drug Discovery against Gastrointestinal Tract Infections.
Keough DT, Wun SJ, Baszczyňski O, Eng WS, Špaček P, Panjikar S, Naesens L, Pohl R, Rejman D, Hocková D, Ferrero RL, Guddat LW.
J Med Chem (2021) 64 : 5710 -5729
PubMed 33891818 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 8.58 9.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2414636 1 9.19
CHEMBL2414703 1 7.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2414636 IC50 = 0.65 nM 9.19
CHEMBL2414703 IC50 = 11.0 nM 7.96