Assay Detail
Binding
CHEMBL4826336
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant LSD1 by horseradish peroxidase-coupled fluorometric assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of novel benzofuran derivatives as potent LSD1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.59 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854446 | — | — | 1 | 7.28 |
| CHEMBL4856172 | — | — | 1 | 7.21 |
| CHEMBL4863608 | — | — | 1 | 7.21 |
| CHEMBL4858199 | — | — | 1 | 7.19 |
| CHEMBL4873407 | — | — | 1 | 7.13 |
| CHEMBL4857710 | — | — | 1 | 7.12 |
| CHEMBL4867217 | — | — | 1 | 7.05 |
| CHEMBL4862184 | — | — | 1 | 6.97 |
| CHEMBL4875708 | — | — | 1 | 6.94 |
| CHEMBL4862965 | — | — | 1 | 6.91 |
| CHEMBL4867394 | — | — | 1 | 6.89 |
| CHEMBL4864707 | — | — | 1 | 6.89 |
| CHEMBL4848676 | — | — | 1 | 6.87 |
| CHEMBL3759201 | — | — | 1 | 6.87 |
| CHEMBL4862640 | — | — | 1 | 6.87 |
| CHEMBL4875303 | — | — | 1 | 6.84 |
| CHEMBL4860041 | — | — | 1 | 6.83 |
| CHEMBL4878035 | — | — | 1 | 6.81 |
| CHEMBL4869351 | — | — | 1 | 6.80 |
| CHEMBL4870715 | — | — | 1 | 6.77 |
| CHEMBL4858064 | — | — | 1 | 6.76 |
| CHEMBL4878624 | — | — | 1 | 6.74 |
| CHEMBL4864665 | — | — | 1 | 6.73 |
| CHEMBL4874220 | — | — | 1 | 6.66 |
| CHEMBL4851421 | — | — | 1 | 6.66 |
| CHEMBL4867816 | — | — | 1 | 6.65 |
| CHEMBL4876005 | — | — | 1 | 6.64 |
| CHEMBL4874997 | — | — | 1 | 6.60 |
| CHEMBL4874246 | — | — | 1 | 6.57 |
| CHEMBL4868387 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854446 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4856172 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4863608 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4858199 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4873407 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4857710 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4867217 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4862184 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4875708 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL4862965 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL4864707 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL4867394 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL4848676 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL3759201 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL4862640 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL4875303 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4860041 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL4878035 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL4869351 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4870715 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4858064 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL4878624 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL4864665 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL4874220 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4851421 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL4867816 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL4876005 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL4874997 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL4874246 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL4868387 | — | IC50 | = | 408.0 | nM | 6.39 |
| CHEMBL4852701 | — | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL4851170 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4871199 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4846305 | — | IC50 | = | 674.0 | nM | 6.17 |
| CHEMBL4876002 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4872237 | — | IC50 | = | 1484.0 | nM | 5.83 |
| CHEMBL4846793 | — | IC50 | = | 2096.0 | nM | 5.68 |
| CHEMBL4874983 | — | IC50 | = | 2616.0 | nM | 5.58 |
| CHEMBL4857917 | — | IC50 | = | 9193.0 | nM | 5.04 |
| CHEMBL4289507 | — | IC50 | = | 40500.0 | nM | 4.39 |