Assay Detail
Functional
CHEMBL4826342
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Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel benzofuran derivatives as potent LSD1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.68 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4848676 | — | — | 1 | 5.80 |
| CHEMBL4856172 | — | — | 1 | 5.73 |
| CHEMBL4857710 | — | — | 1 | 5.72 |
| CHEMBL4863608 | — | — | 1 | 5.69 |
| CHEMBL4854446 | — | — | 1 | 5.67 |
| CHEMBL3759201 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4848676 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL4856172 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL4857710 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4863608 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL4854446 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL3759201 | — | IC50 | = | 3390.0 | nM | 5.47 |