Assay Detail
Functional
CHEMBL4826343
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel benzofuran derivatives as potent LSD1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.29 | 5.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4857710 | — | — | 1 | 5.61 |
| CHEMBL4856172 | — | — | 1 | 5.39 |
| CHEMBL4854446 | — | — | 1 | 5.26 |
| CHEMBL4863608 | — | — | 1 | 5.24 |
| CHEMBL4848676 | — | — | 1 | 5.20 |
| CHEMBL3759201 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4857710 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL4856172 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL4854446 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4863608 | — | IC50 | = | 5740.0 | nM | 5.24 |
| CHEMBL4848676 | — | IC50 | = | 6330.0 | nM | 5.20 |
| CHEMBL3759201 | — | IC50 | = | 9730.0 | nM | 5.01 |