Assay Detail
Functional
CHEMBL4826798
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Antiproliferative activity against human HT29 cells assessed as reduction in cell viability incubated for 48 hr by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of chalcone-polyamine conjugates as novel vectorized agents in colorectal and prostate cancer chemotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.83 | 5.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227779 | — | — | 1 | 5.13 |
| CHEMBL4871983 | — | — | 1 | 4.97 |
| CHEMBL4859720 | — | — | 1 | 4.86 |
| CHEMBL4878713 | — | — | 1 | 4.70 |
| CHEMBL4854397 | — | — | 1 | 4.50 |
| CHEMBL4870619 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227779 | — | IC50 | = | 7440.0 | nM | 5.13 |
| CHEMBL4871983 | — | IC50 | = | 10760.0 | nM | 4.97 |
| CHEMBL4859720 | — | IC50 | = | 13670.0 | nM | 4.86 |
| CHEMBL4878713 | — | IC50 | = | 20160.0 | nM | 4.70 |
| CHEMBL4854397 | — | IC50 | = | 31760.0 | nM | 4.50 |
| CHEMBL4870619 | — | IC50 | > | 40000.0 | nM | - |