Assay Detail
Functional
CHEMBL4827059
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 infected in African Green monkey Vero E6 cells assessed as reduction in viral plaques in presence of efflux inhibitor CP-100356 incubated for 48 hrs by quantitative RT-PCR assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Improved SARS-CoV-2 M<sup>pro</sup> inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 6.50 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4860690 | — | — | 1 | 6.75 |
| CHEMBL4868443 | — | — | 1 | 6.72 |
| CHEMBL4851462 | — | — | 1 | 6.60 |
| CHEMBL3427166 | — | — | 1 | 6.60 |
| CHEMBL4862798 | — | — | 1 | 6.60 |
| CHEMBL4873422 | — | — | 1 | 6.57 |
| CHEMBL4847583 | — | — | 1 | 6.55 |
| CHEMBL4860766 | — | — | 1 | 6.54 |
| CHEMBL4846637 | — | — | 1 | 6.50 |
| CHEMBL4855575 | — | — | 1 | 6.50 |
| CHEMBL4850298 | — | — | 1 | 6.50 |
| CHEMBL4866337 | — | — | 1 | 6.40 |
| CHEMBL4852620 | — | — | 1 | 6.30 |
| CHEMBL4856934 | — | — | 1 | 5.92 |
| CHEMBL4856186 | — | — | 1 | - |
| CHEMBL4861886 | — | — | 1 | - |
| CHEMBL4856003 | — | — | 1 | - |
| CHEMBL4878333 | — | — | 1 | - |
| CHEMBL478401 | — | — | 1 | - |
| CHEMBL3427168 | — | — | 1 | - |
| CHEMBL4856219 | — | — | 1 | - |
| CHEMBL4850660 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4860690 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4868443 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4851462 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3427166 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4862798 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4873422 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4847583 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4860766 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4846637 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4855575 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4850298 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4866337 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4852620 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4856934 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4856186 | — | EC50 | - | — | - | |
| CHEMBL4861886 | — | EC50 | - | — | - | |
| CHEMBL4856003 | — | EC50 | - | — | - | |
| CHEMBL4878333 | — | EC50 | - | — | - | |
| CHEMBL478401 | — | EC50 | - | — | - | |
| CHEMBL3427168 | — | EC50 | - | — | - | |
| CHEMBL4856219 | — | EC50 | - | — | - | |
| CHEMBL4850660 | — | EC50 | - | — | - |