Assay Detail
Binding
CHEMBL4827616
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Inhibition of NanoLuc-fused CAMKK2 (unknown origin) expressed in HEK293 cells after 24 hrs by NanoBRET assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Calcium/calmodulin-dependent protein kinase kinase 2 (CHEMBL5284) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.48 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4870467 | — | — | 1 | 8.09 |
| CHEMBL4852523 | — | — | 1 | 6.85 |
| CHEMBL4862562 | — | — | 1 | 6.77 |
| CHEMBL4877552 | — | — | 1 | 6.72 |
| CHEMBL4851925 | — | — | 1 | 6.70 |
| CHEMBL4875005 | — | — | 1 | 6.68 |
| CHEMBL4869147 | — | — | 1 | 6.62 |
| CHEMBL4876404 | — | — | 1 | 6.54 |
| CHEMBL4873692 | — | — | 1 | 6.33 |
| CHEMBL4851892 | — | — | 1 | 6.28 |
| CHEMBL4877634 | — | — | 1 | 6.27 |
| CHEMBL4866741 | — | — | 1 | 6.16 |
| CHEMBL4849143 | — | — | 1 | 6.05 |
| CHEMBL4857601 | — | — | 1 | 6.02 |
| CHEMBL4853274 | — | — | 1 | 5.85 |
| CHEMBL4878827 | — | — | 1 | 5.72 |
| CHEMBL4125686 | — | — | 1 | - |
| CHEMBL4857253 | — | — | 1 | - |
| CHEMBL558642 | GSK-650394 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4870467 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL4852523 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4862562 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4877552 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4851925 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4875005 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4869147 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4876404 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4873692 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4851892 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4877634 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4866741 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4849143 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4857601 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4853274 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4878827 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4125686 | — | IC50 | - | — | - | |
| CHEMBL4857253 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL558642 | GSK-650394 | IC50 | < | 3.0 | nM | - |