Assay Detail
Binding
CHEMBL4827620
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CAMKK2 in human LNCaP C4-2 cells assessed as reduction AMPK phosphorylation at Thr172 incubated for 24 hrs by Western blot analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LNCaP C4-2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Calcium/calmodulin-dependent protein kinase kinase 2 (CHEMBL5284) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.81 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4852523 | — | — | 1 | 6.41 |
| CHEMBL4876404 | — | — | 1 | 6.10 |
| CHEMBL4877552 | — | — | 1 | 6.05 |
| CHEMBL4869147 | — | — | 1 | 6.01 |
| CHEMBL4870467 | — | — | 1 | 5.75 |
| CHEMBL4125686 | — | — | 1 | 5.26 |
| CHEMBL4862562 | — | — | 1 | 5.09 |
| CHEMBL4857253 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4852523 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4876404 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4877552 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4869147 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4870467 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4125686 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4862562 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4857253 | — | IC50 | < | 39.0 | nM | - |