Assay Detail
Binding
CHEMBL4827634
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Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyruvate and NADPH addition
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.96 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4850573 | — | — | 1 | 10.15 |
| CHEMBL4855986 | — | — | 1 | 10.00 |
| CHEMBL4861379 | — | — | 1 | 9.52 |
| CHEMBL4847068 | — | — | 1 | 9.52 |
| CHEMBL4873879 | — | — | 1 | 9.40 |
| CHEMBL4864519 | — | — | 1 | 9.30 |
| CHEMBL4081890 | — | — | 1 | 7.50 |
| CHEMBL2059811 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4850573 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL4855986 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4861379 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4847068 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4873879 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4864519 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4081890 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2059811 | — | IC50 | = | 500.0 | nM | 6.30 |