Assay Detail
Binding
CHEMBL4827638
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GOX/LDHA in Ag xt knockdown PH1 mouse primary hepatocyte assessed as reduction of oxalate production in the presence of glycolate measured after 2 hrs by ICMS analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Primary hepatocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.88 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4864519 | — | — | 1 | 7.06 |
| CHEMBL4857427 | — | — | 1 | 6.83 |
| CHEMBL4081890 | — | — | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4864519 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4857427 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL4081890 | — | IC50 | = | 181.0 | nM | 6.74 |