Assay Detail
Binding
CHEMBL4828007
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant FLAG-tagged HDAC1 expressed in HEK293F cells incubated for 30 mins by Fluor De Lys assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293F |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Histone Deacetylase Inhibitors for Treating HIV Infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.60 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4861467 | — | — | 1 | 10.30 |
| CHEMBL4862152 | — | — | 1 | 9.77 |
| CHEMBL4861271 | — | — | 1 | 9.49 |
| CHEMBL4862556 | — | — | 1 | 8.82 |
| CHEMBL4873493 | — | — | 1 | - |
| CHEMBL4864510 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4861467 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL4862152 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL4861271 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL4862556 | — | IC50 | = | 1.52 | nM | 8.82 |
| CHEMBL4873493 | — | IC50 | < | 1.5 | nM | - |
| CHEMBL4864510 | — | IC50 | < | 1.5 | nM | - |