Assay Detail
Binding
CHEMBL4828237
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to BPTF (unknown origin) by by BROMOscan method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nucleosome-remodeling factor subunit BPTF (CHEMBL3085621) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.52 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4872300 | — | — | 1 | 8.20 |
| CHEMBL4861491 | — | — | 1 | 8.03 |
| CHEMBL4848701 | — | — | 1 | 7.16 |
| CHEMBL4863631 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4872300 | — | Kd | = | 6.3 | nM | 8.20 |
| CHEMBL4861491 | — | Kd | = | 9.3 | nM | 8.03 |
| CHEMBL4848701 | — | Kd | = | 70.0 | nM | 7.16 |
| CHEMBL4863631 | — | Kd | = | 200.0 | nM | 6.70 |