Assay Detail
Binding
CHEMBL4828252
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MKN2 (unknown origin) in presence of ATP by HTRF assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
MAP kinase-interacting serine/threonine-protein kinase 2 (CHEMBL4204) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of 4,6-Disubstituted Pyrido[3,2-<i>d</i>]pyrimidines as Dual MNK/PIM Inhibitors to Inhibit Leukemia Cell Growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.59 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4869634 | — | — | 1 | 8.15 |
| CHEMBL4872538 | — | — | 1 | 8.00 |
| CHEMBL4859971 | — | — | 1 | 7.60 |
| CHEMBL4876307 | — | — | 1 | 7.58 |
| CHEMBL4857156 | — | — | 1 | 7.54 |
| CHEMBL4859617 | — | — | 1 | 7.48 |
| CHEMBL4853562 | — | — | 1 | 7.44 |
| CHEMBL4861251 | — | — | 1 | 7.39 |
| CHEMBL4848753 | — | — | 1 | 7.39 |
| CHEMBL4879010 | — | — | 1 | 7.37 |
| CHEMBL4858115 | — | — | 1 | 7.28 |
| CHEMBL4861078 | — | — | 1 | 7.24 |
| CHEMBL4849911 | — | — | 1 | 7.21 |
| CHEMBL4864209 | — | — | 1 | 6.96 |
| CHEMBL4866350 | — | — | 1 | 6.21 |
| CHEMBL4846164 | — | — | 1 | 6.21 |
| CHEMBL1240885 | — | — | 1 | 5.80 |
| CHEMBL4850233 | — | — | 1 | 5.75 |
| CHEMBL4855483 | — | — | 1 | 5.72 |
| CHEMBL4866279 | — | — | 1 | 5.72 |
| CHEMBL4874353 | — | — | 1 | 5.66 |
| CHEMBL4856576 | — | — | 1 | 5.60 |
| CHEMBL4872712 | — | — | 1 | 5.41 |
| CHEMBL4875475 | — | — | 1 | 5.38 |
| CHEMBL4860143 | — | — | 1 | 5.32 |
| CHEMBL4848439 | — | — | 1 | 5.31 |
| CHEMBL4867333 | — | — | 1 | 5.30 |
| CHEMBL4873909 | — | — | 1 | - |
| CHEMBL4872456 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4869634 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4872538 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4859971 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4876307 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4857156 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4859617 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4853562 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4861251 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4848753 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4879010 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4858115 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4861078 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4849911 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4864209 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL4866350 | — | IC50 | = | 612.0 | nM | 6.21 |
| CHEMBL4846164 | — | IC50 | = | 624.0 | nM | 6.21 |
| CHEMBL1240885 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4850233 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4855483 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4866279 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4874353 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4856576 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4872712 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4875475 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4860143 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4848439 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4867333 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4873909 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4872456 | — | IC50 | > | 10000.0 | nM | - |