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Assay Detail

CHEMBL4828385

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Anti wolbachia activity against Wolbachia infected in Aedes albopictus C6/36 assessed as reduction in mosquito infection
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Wolbachia
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Development of Pyrazolopyrimidine Anti-<i>Wolbachia</i> Agents for the Treatment of Filariasis.
McGillan P, Berry NG, Nixon GL, Leung SC, Webborn PJH, Wenlock MC, Kavanagh S, Cassidy A, Clare RH, Cook DA, Johnston KL, Ford L, Ward SA, Taylor MJ, Hong WD, O'Neill PM.
ACS Med Chem Lett (2021) 12 : 1421 -1426
PubMed 34527179 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 19 6.98 7.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4855056 1 7.96
CHEMBL1200699 DOXYCYCLINE 4.0 1 7.77
CHEMBL4874367 1 7.77
CHEMBL4860345 1 7.72
CHEMBL4868048 1 7.68
CHEMBL4868989 1 7.42
CHEMBL4873200 1 7.37
CHEMBL4852539 1 7.29
CHEMBL4868573 1 7.28
CHEMBL4860513 1 7.10
CHEMBL4853016 1 7.03
CHEMBL4866002 1 6.98
CHEMBL4868410 1 6.92
CHEMBL4868880 1 6.84
CHEMBL4863149 1 6.18
CHEMBL4864252 1 6.15
CHEMBL4876105 1 6.00
CHEMBL4873374 1 5.60
CHEMBL4851130 1 5.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4855056 EC50 = 11.0 nM 7.96
CHEMBL1200699 DOXYCYCLINE EC50 = 17.0 nM 7.77
CHEMBL4874367 EC50 = 17.0 nM 7.77
CHEMBL4860345 EC50 = 19.0 nM 7.72
CHEMBL4868048 EC50 = 21.0 nM 7.68
CHEMBL4868989 EC50 = 38.0 nM 7.42
CHEMBL4873200 EC50 = 43.0 nM 7.37
CHEMBL4852539 EC50 = 51.0 nM 7.29
CHEMBL4868573 EC50 = 52.0 nM 7.28
CHEMBL4860513 EC50 = 79.0 nM 7.10
CHEMBL4853016 EC50 = 93.0 nM 7.03
CHEMBL4866002 EC50 = 105.0 nM 6.98
CHEMBL4868410 EC50 = 119.0 nM 6.92
CHEMBL4868880 EC50 = 143.0 nM 6.84
CHEMBL4863149 EC50 = 664.0 nM 6.18
CHEMBL4864252 EC50 = 704.0 nM 6.15
CHEMBL4876105 EC50 = 1000.0 nM 6.00
CHEMBL4873374 EC50 = 2500.0 nM 5.60
CHEMBL4851130 EC50 = 2500.0 nM 5.60