Assay Detail
Functional
CHEMBL4828519
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human KARPAS-422 cells assessed as cell growth incubated for 7 days by lactate dehydrogenase based WST-8 assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KARPAS-422 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 8.31 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4859559 | — | — | 1 | 9.30 |
| CHEMBL4869420 | — | — | 1 | 9.05 |
| CHEMBL4850823 | — | — | 1 | 9.00 |
| CHEMBL4877375 | — | — | 1 | 9.00 |
| CHEMBL4861394 | — | — | 1 | 8.92 |
| CHEMBL4854800 | — | — | 1 | 8.92 |
| CHEMBL4870920 | — | — | 1 | 8.92 |
| CHEMBL4871261 | — | — | 1 | 8.89 |
| CHEMBL4861749 | — | — | 1 | 8.85 |
| CHEMBL4855616 | — | — | 1 | 8.85 |
| CHEMBL4850847 | — | — | 1 | 8.82 |
| CHEMBL4873268 | — | — | 1 | 8.72 |
| CHEMBL4857414 | — | — | 1 | 8.72 |
| CHEMBL4856280 | — | — | 1 | 8.70 |
| CHEMBL4878932 | — | — | 1 | 8.66 |
| CHEMBL4858089 | — | — | 1 | 8.62 |
| CHEMBL4860499 | — | — | 1 | 8.51 |
| CHEMBL4856160 | — | — | 1 | 8.41 |
| CHEMBL4851576 | — | — | 1 | 8.38 |
| CHEMBL4847943 | — | — | 1 | 8.36 |
| CHEMBL4849266 | — | — | 1 | 8.34 |
| CHEMBL4858561 | — | — | 1 | 8.20 |
| CHEMBL4877695 | — | — | 1 | 8.18 |
| CHEMBL4872891 | — | — | 1 | 8.10 |
| CHEMBL4865691 | — | — | 1 | 8.09 |
| CHEMBL4862163 | — | — | 1 | 8.08 |
| CHEMBL4854206 | — | — | 1 | 7.83 |
| CHEMBL4847397 | — | — | 1 | 7.76 |
| CHEMBL4869720 | — | — | 1 | 7.54 |
| CHEMBL4869748 | — | — | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4859559 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4869420 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4850823 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4877375 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4861394 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4854800 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4870920 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4871261 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4861749 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4855616 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4850847 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4873268 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4857414 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4856280 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4878932 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4858089 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4860499 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4856160 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4851576 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4847943 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4849266 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4858561 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4877695 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4872891 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL4865691 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL4862163 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL4854206 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL4847397 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL4869720 | — | IC50 | = | 29.2 | nM | 7.54 |
| CHEMBL4869748 | — | IC50 | = | 37.1 | nM | 7.43 |
| CHEMBL4869208 | — | IC50 | = | 51.5 | nM | 7.29 |
| CHEMBL4858622 | — | IC50 | = | 57.8 | nM | 7.24 |
| CHEMBL4104741 | — | IC50 | = | 62.9 | nM | 7.20 |
| CHEMBL4861770 | — | IC50 | = | 68.3 | nM | 7.17 |
| CHEMBL4065484 | — | IC50 | = | 125.4 | nM | 6.90 |