Assay Detail
Binding
CHEMBL4829316
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Zinc chelation-dependent inhibition of VIM-2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using nitrocefin as substrate preincubated with enzyme for 5 to 10 mins followed by substrate addition
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
H<sub>2</sub>dpa derivatives containing pentadentate ligands: An acyclic adjuvant potentiates meropenem activity in vitro and in vivo against metallo-β-lactamase-producing Enterobacterales.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.62 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4873457 | — | — | 1 | 5.98 |
| CHEMBL4849628 | — | — | 1 | 5.82 |
| CHEMBL4854653 | — | — | 1 | 5.81 |
| CHEMBL4876716 | — | — | 1 | 5.81 |
| CHEMBL4878642 | — | — | 1 | 5.69 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 4.63 |
| CHEMBL4059535 | — | — | 1 | - |
| CHEMBL858 | EDETIC ACID | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4873457 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4849628 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4854653 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4876716 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL4878642 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL4059535 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL858 | EDETIC ACID | IC50 | > | 200000.0 | nM | - |