Assay Detail
Binding
CHEMBL4829352
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Non competitive inhibition of VIM-2 (unknown origin) assessed as inhibition of substrate hydrolysis by measuring decrease in Vmax using nitrocefin as substrate preincubated with enzyme for 5 mins followed by substrate addition by Lineweaver-Burk plot analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
H<sub>2</sub>dpa derivatives containing pentadentate ligands: An acyclic adjuvant potentiates meropenem activity in vitro and in vivo against metallo-β-lactamase-producing Enterobacterales.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.22 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4876716 | — | — | 1 | 5.23 |
| CHEMBL4854653 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4876716 | — | Ki | = | 5830.0 | nM | 5.23 |
| CHEMBL4854653 | — | Ki | = | 6160.0 | nM | 5.21 |