Assay Detail
Binding
CHEMBL4829379
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Inhibition of human 20S proteasome X using Ac-WLA-AMC as fluorogenic substrate measured every minute for 1 hr by fluorescence assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.43 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4867231 | — | — | 1 | 5.97 |
| CHEMBL4877277 | — | — | 1 | 5.33 |
| CHEMBL4863075 | — | — | 1 | 5.33 |
| CHEMBL4879354 | — | — | 1 | 5.32 |
| CHEMBL4863666 | — | — | 1 | 5.30 |
| CHEMBL4875393 | — | — | 1 | 5.30 |
| CHEMBL4845896 | — | — | 1 | - |
| CHEMBL4649310 | — | — | 1 | - |
| CHEMBL4879280 | — | — | 1 | - |
| CHEMBL4646371 | — | — | 1 | - |
| CHEMBL4863407 | — | — | 1 | - |
| CHEMBL4864020 | — | — | 1 | - |
| CHEMBL4867229 | — | — | 1 | - |
| CHEMBL4870740 | — | — | 1 | - |
| CHEMBL4855585 | — | — | 1 | - |
| CHEMBL4869559 | — | — | 1 | - |
| CHEMBL4854647 | — | — | 1 | - |
| CHEMBL4866610 | — | — | 1 | - |
| CHEMBL4849360 | — | — | 1 | - |
| CHEMBL4859824 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4867231 | — | IC50 | = | 1081.0 | nM | 5.97 |
| CHEMBL4877277 | — | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL4863075 | — | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL4879354 | — | IC50 | = | 4766.0 | nM | 5.32 |
| CHEMBL4863666 | — | IC50 | = | 4998.0 | nM | 5.30 |
| CHEMBL4875393 | — | IC50 | = | 4998.0 | nM | 5.30 |
| CHEMBL4845896 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4649310 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4879280 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4646371 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4863407 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4864020 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4867229 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4870740 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4855585 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4869559 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4854647 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4866610 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4849360 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4859824 | — | IC50 | > | 10000.0 | nM | - |