Assay Detail
Binding
CHEMBL4829383
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human 20S proteasome LMP2 activity in human RPMI-8226 cells using Ac-PAL-AMC as fluorogenic substrate incubated for 72 hrs by fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.49 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4845896 | — | — | 1 | 7.55 |
| CHEMBL4646371 | — | — | 1 | 7.51 |
| CHEMBL4877277 | — | — | 1 | 7.49 |
| CHEMBL4879354 | — | — | 1 | 7.47 |
| CHEMBL4867231 | — | — | 1 | 7.45 |
| CHEMBL4867229 | — | — | 1 | - |
| CHEMBL4870740 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4845896 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4646371 | — | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL4877277 | — | IC50 | = | 32.7 | nM | 7.49 |
| CHEMBL4879354 | — | IC50 | = | 33.9 | nM | 7.47 |
| CHEMBL4867231 | — | IC50 | = | 35.8 | nM | 7.45 |
| CHEMBL4867229 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4870740 | — | IC50 | > | 10000.0 | nM | - |