Assay Detail
Functional
CHEMBL4829409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT116 p53-null cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT116-p53-null |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Substituted dienes prepared from betulinic acid - Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 4.56 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1078221 | — | — | 1 | 5.72 |
| CHEMBL4867351 | — | — | 1 | 4.82 |
| CHEMBL4856107 | — | — | 1 | 4.80 |
| CHEMBL4860726 | — | — | 1 | 4.74 |
| CHEMBL4847726 | — | — | 1 | 4.68 |
| CHEMBL4867012 | — | — | 1 | 4.68 |
| CHEMBL4858907 | — | — | 1 | 4.68 |
| CHEMBL4852556 | — | — | 1 | 4.65 |
| CHEMBL4858954 | — | — | 1 | 4.65 |
| CHEMBL4870500 | — | — | 1 | 4.61 |
| CHEMBL4877436 | — | — | 1 | 4.61 |
| CHEMBL4863253 | — | — | 1 | 4.61 |
| CHEMBL4873435 | — | — | 1 | 4.61 |
| CHEMBL4853477 | — | — | 1 | 4.59 |
| CHEMBL4877859 | — | — | 1 | 4.58 |
| CHEMBL4859297 | — | — | 1 | 4.57 |
| CHEMBL4870312 | — | — | 1 | 4.53 |
| CHEMBL4854487 | — | — | 1 | 4.53 |
| CHEMBL4847755 | — | — | 1 | 4.53 |
| CHEMBL4846166 | — | — | 1 | 4.51 |
| CHEMBL4856989 | — | — | 1 | 4.50 |
| CHEMBL4868836 | — | — | 1 | 4.50 |
| CHEMBL4868329 | — | — | 1 | 4.48 |
| CHEMBL4855697 | — | — | 1 | 4.48 |
| CHEMBL4857935 | — | — | 1 | 4.47 |
| CHEMBL4874438 | — | — | 1 | 4.45 |
| CHEMBL4862869 | — | — | 1 | 4.44 |
| CHEMBL4857505 | — | — | 1 | 4.44 |
| CHEMBL4854755 | — | — | 1 | 4.42 |
| CHEMBL4851234 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1078221 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4867351 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL4856107 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL4860726 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL4847726 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL4867012 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL4858907 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4852556 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL4858954 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL4863253 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL4873435 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL4877436 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL4870500 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL4853477 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL4877859 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL4859297 | — | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL4870312 | — | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL4854487 | — | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL4847755 | — | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL4846166 | — | IC50 | = | 30600.0 | nM | 4.51 |
| CHEMBL4856989 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL4868836 | — | IC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL4868329 | — | IC50 | = | 32800.0 | nM | 4.48 |
| CHEMBL4855697 | — | IC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL4857935 | — | IC50 | = | 33600.0 | nM | 4.47 |
| CHEMBL4874438 | — | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL4862869 | — | IC50 | = | 36100.0 | nM | 4.44 |
| CHEMBL4857505 | — | IC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL4854755 | — | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL4851234 | — | IC50 | = | 39300.0 | nM | 4.41 |
| CHEMBL4864485 | — | IC50 | = | 39600.0 | nM | 4.40 |
| CHEMBL4861184 | — | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL4858667 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4867789 | — | IC50 | = | 42500.0 | nM | 4.37 |
| CHEMBL4857843 | — | IC50 | = | 43100.0 | nM | 4.37 |
| CHEMBL4866819 | — | IC50 | = | 43300.0 | nM | 4.36 |
| CHEMBL4853391 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL4867620 | — | IC50 | = | 48900.0 | nM | 4.31 |
| CHEMBL4873190 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4862824 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4850777 | — | IC50 | > | 50000.0 | nM | - |