Assay Detail
Functional
CHEMBL4829413
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human U2OS cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted dienes prepared from betulinic acid - Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 4.58 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1078221 | — | — | 1 | 5.66 |
| CHEMBL4867351 | — | — | 1 | 4.76 |
| CHEMBL4858954 | — | — | 1 | 4.74 |
| CHEMBL4856107 | — | — | 1 | 4.71 |
| CHEMBL4847726 | — | — | 1 | 4.65 |
| CHEMBL4877436 | — | — | 1 | 4.62 |
| CHEMBL4858667 | — | — | 1 | 4.62 |
| CHEMBL4861184 | — | — | 1 | 4.62 |
| CHEMBL4870500 | — | — | 1 | 4.61 |
| CHEMBL4864485 | — | — | 1 | 4.60 |
| CHEMBL4854755 | — | — | 1 | 4.59 |
| CHEMBL4867012 | — | — | 1 | 4.58 |
| CHEMBL4868836 | — | — | 1 | 4.57 |
| CHEMBL4877859 | — | — | 1 | 4.57 |
| CHEMBL4859297 | — | — | 1 | 4.56 |
| CHEMBL4852556 | — | — | 1 | 4.56 |
| CHEMBL4858907 | — | — | 1 | 4.56 |
| CHEMBL4873435 | — | — | 1 | 4.56 |
| CHEMBL4854487 | — | — | 1 | 4.55 |
| CHEMBL4863253 | — | — | 1 | 4.55 |
| CHEMBL4853477 | — | — | 1 | 4.55 |
| CHEMBL4856989 | — | — | 1 | 4.55 |
| CHEMBL4870312 | — | — | 1 | 4.54 |
| CHEMBL4874438 | — | — | 1 | 4.53 |
| CHEMBL4857935 | — | — | 1 | 4.53 |
| CHEMBL4846166 | — | — | 1 | 4.53 |
| CHEMBL4862869 | — | — | 1 | 4.53 |
| CHEMBL4857505 | — | — | 1 | 4.52 |
| CHEMBL4868329 | — | — | 1 | 4.51 |
| CHEMBL4855697 | — | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1078221 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4867351 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL4858954 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL4856107 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL4847726 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL4877436 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL4858667 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL4861184 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL4870500 | — | IC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL4864485 | — | IC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL4854755 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL4867012 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL4868836 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4877859 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL4873435 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL4859297 | — | IC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL4858907 | — | IC50 | = | 27700.0 | nM | 4.56 |
| CHEMBL4852556 | — | IC50 | = | 27700.0 | nM | 4.56 |
| CHEMBL4856989 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL4853477 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4854487 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL4863253 | — | IC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL4870312 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL4874438 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL4857935 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL4846166 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL4862869 | — | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL4857505 | — | IC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL4868329 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL4855697 | — | IC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL4851234 | — | IC50 | = | 33100.0 | nM | 4.48 |
| CHEMBL4853391 | — | IC50 | = | 40400.0 | nM | 4.39 |
| CHEMBL4866819 | — | IC50 | = | 44100.0 | nM | 4.36 |
| CHEMBL4873190 | — | IC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL4867789 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL4867620 | — | IC50 | = | 48600.0 | nM | 4.31 |
| CHEMBL4860726 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4850777 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4857843 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4847755 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4862824 | — | IC50 | > | 50000.0 | nM | - |