Assay Detail
Functional
CHEMBL4829466
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Cytotoxicity against human NCI-H460 cells harboring wild type EGFR assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The synthesis and bioactivity of pyrrolo[2,3-d]pyrimidine derivatives as tyrosine kinase inhibitors for NSCLC cells with EGFR mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.95 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4873503 | — | — | 1 | 5.33 |
| CHEMBL4862044 | — | — | 1 | 5.31 |
| CHEMBL4297865 | ABIVERTINIB | 3.0 | 1 | 5.22 |
| CHEMBL4846913 | — | — | 1 | 5.12 |
| CHEMBL4850239 | — | — | 1 | 5.10 |
| CHEMBL4847264 | — | — | 1 | 4.57 |
| CHEMBL4860999 | — | — | 1 | 4.47 |
| CHEMBL3787662 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4873503 | — | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL4862044 | — | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL4297865 | ABIVERTINIB | IC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL4846913 | — | IC50 | = | 7650.0 | nM | 5.12 |
| CHEMBL4850239 | — | IC50 | = | 8020.0 | nM | 5.10 |
| CHEMBL4847264 | — | IC50 | = | 26670.0 | nM | 4.57 |
| CHEMBL4860999 | — | IC50 | = | 33580.0 | nM | 4.47 |
| CHEMBL3787662 | — | IC50 | = | 36020.0 | nM | 4.44 |