Assay Detail
Binding
CHEMBL4829967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST-tagged human BPTF (2914 to 3037 residues) expressed in Escherichia coli BL21-CodonPlus (DE3) cells by HTRF assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nucleosome-remodeling factor subunit BPTF (CHEMBL3085621) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of High-Affinity Inhibitors of the BPTF Bromodomain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.72 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4860578 | — | — | 1 | 7.80 |
| CHEMBL4873042 | — | — | 1 | 7.57 |
| CHEMBL4870170 | — | — | 1 | 7.54 |
| CHEMBL4867072 | — | — | 1 | 7.49 |
| CHEMBL4868713 | — | — | 1 | 7.43 |
| CHEMBL4866637 | — | — | 1 | 7.23 |
| CHEMBL4851594 | — | — | 1 | 7.23 |
| CHEMBL4862619 | — | — | 1 | 7.20 |
| CHEMBL4852588 | — | — | 1 | 6.94 |
| CHEMBL4853486 | — | — | 1 | 6.84 |
| CHEMBL4861221 | — | — | 1 | 6.80 |
| CHEMBL4863921 | — | — | 1 | 6.54 |
| CHEMBL4861375 | — | — | 1 | 6.16 |
| CHEMBL4872350 | — | — | 1 | 5.77 |
| CHEMBL4872974 | — | — | 1 | 5.68 |
| CHEMBL4863800 | — | — | 1 | 5.11 |
| CHEMBL4875586 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4860578 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4873042 | — | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL4870170 | — | IC50 | = | 28.8 | nM | 7.54 |
| CHEMBL4867072 | — | IC50 | = | 32.7 | nM | 7.49 |
| CHEMBL4868713 | — | IC50 | = | 36.9 | nM | 7.43 |
| CHEMBL4866637 | — | IC50 | = | 58.6 | nM | 7.23 |
| CHEMBL4851594 | — | IC50 | = | 59.3 | nM | 7.23 |
| CHEMBL4862619 | — | IC50 | = | 63.8 | nM | 7.20 |
| CHEMBL4852588 | — | IC50 | = | 113.8 | nM | 6.94 |
| CHEMBL4853486 | — | IC50 | = | 145.4 | nM | 6.84 |
| CHEMBL4861221 | — | IC50 | = | 157.3 | nM | 6.80 |
| CHEMBL4863921 | — | IC50 | = | 287.6 | nM | 6.54 |
| CHEMBL4861375 | — | IC50 | = | 698.3 | nM | 6.16 |
| CHEMBL4872350 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4872974 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4863800 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4875586 | — | IC50 | = | 14700.0 | nM | 4.83 |