Assay Detail
Binding
CHEMBL4829969
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to N-terminal GST-tagged human BPTF (2914 to 3037 residues) expressed in Escherichia coli BL21-CodonPlus (DE3) cells by SPR assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nucleosome-remodeling factor subunit BPTF (CHEMBL3085621) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of High-Affinity Inhibitors of the BPTF Bromodomain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 4.84 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4861375 | — | — | 1 | 5.55 |
| CHEMBL4873042 | — | — | 1 | 4.68 |
| CHEMBL4860578 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4861375 | — | Kd | = | 2810.0 | nM | 5.55 |
| CHEMBL4873042 | — | Kd | = | 20700.0 | nM | 4.68 |
| CHEMBL4860578 | — | Kd | = | 49600.0 | nM | 4.30 |