Assay Detail
Binding
CHEMBL4830003
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by SPR analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nucleosome-remodeling factor subunit BPTF (CHEMBL3085621) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of High-Affinity Inhibitors of the BPTF Bromodomain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.90 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4461619 | — | — | 1 | 6.70 |
| CHEMBL4069412 | — | — | 1 | 5.77 |
| CHEMBL4867912 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4461619 | — | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL4069412 | — | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL4867912 | — | Kd | = | 6000.0 | nM | 5.22 |