Assay Detail
Functional
CHEMBL4830028
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Antiproliferative activity against human 786-0 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 786-0 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of <i>N</i>-((3<i>S</i>,4<i>S</i>)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1<i>H</i>-pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.43 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4867422 | — | — | 1 | 6.02 |
| CHEMBL4874391 | — | — | 1 | 6.00 |
| CHEMBL4873815 | — | — | 1 | 5.72 |
| CHEMBL4868266 | — | — | 1 | 5.66 |
| CHEMBL4866810 | — | — | 1 | 5.65 |
| CHEMBL4556790 | — | — | 1 | 5.60 |
| CHEMBL4877032 | — | — | 1 | 5.50 |
| CHEMBL4878473 | — | — | 1 | 5.49 |
| CHEMBL4859898 | — | — | 1 | 5.45 |
| CHEMBL4875495 | — | — | 1 | 5.42 |
| CHEMBL4858782 | — | — | 1 | 5.39 |
| CHEMBL4873154 | — | — | 1 | 5.37 |
| CHEMBL4855363 | — | — | 1 | 5.30 |
| CHEMBL4847466 | — | — | 1 | 5.28 |
| CHEMBL4854839 | — | — | 1 | 5.15 |
| CHEMBL4877044 | — | — | 1 | 5.11 |
| CHEMBL4868168 | — | — | 1 | 5.10 |
| CHEMBL4852887 | — | — | 1 | 4.59 |
| CHEMBL4869482 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4867422 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4874391 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL4873815 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4868266 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4866810 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL4556790 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4877032 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL4878473 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL4859898 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL4875495 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL4858782 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL4873154 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL4855363 | — | IC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL4847466 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4854839 | — | IC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL4877044 | — | IC50 | = | 7810.0 | nM | 5.11 |
| CHEMBL4868168 | — | IC50 | = | 7990.0 | nM | 5.10 |
| CHEMBL4852887 | — | IC50 | = | 25510.0 | nM | 4.59 |
| CHEMBL4869482 | — | IC50 | - | — | - |