Assay Detail
Functional
CHEMBL4830155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human COLO 205 cells assessed as reduction in cell viability after 96 hrs by alamar blue assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.87 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4847260 | BEROTERKIB ANHYDROUS | 2.0 | 1 | 8.44 |
| CHEMBL4847212 | — | — | 1 | 8.38 |
| CHEMBL4212211 | — | — | 1 | 8.12 |
| CHEMBL4867689 | — | — | 1 | 8.10 |
| CHEMBL4870129 | — | — | 1 | 8.00 |
| CHEMBL4873400 | — | — | 1 | 7.92 |
| CHEMBL4869800 | — | — | 1 | 7.82 |
| CHEMBL4873851 | — | — | 1 | 7.82 |
| CHEMBL4866448 | — | — | 1 | 7.57 |
| CHEMBL4865318 | — | — | 1 | 7.31 |
| CHEMBL4213466 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4847260 | BEROTERKIB ANHYDROUS | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4847212 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4212211 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4867689 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4870129 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4873400 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4869800 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4873851 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4866448 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4865318 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4213466 | — | IC50 | = | 73.0 | nM | 7.14 |