Assay Detail
Functional
CHEMBL4830274
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human HeLa cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 reagent assay
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Study on the structure-activity relationship of dihydroartemisinin derivatives: Discovery, synthesis, and biological evaluation of dihydroartemisinin-bile acid conjugates as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 56 | 5.92 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4859691 | — | — | 1 | 7.40 |
| CHEMBL4864551 | — | — | 1 | 7.10 |
| CHEMBL4863326 | — | — | 1 | 6.80 |
| CHEMBL4872477 | — | — | 1 | 6.72 |
| CHEMBL4854462 | — | — | 1 | 6.62 |
| CHEMBL4875175 | — | — | 1 | 6.48 |
| CHEMBL4862637 | — | — | 1 | 6.41 |
| CHEMBL4857828 | — | — | 1 | 6.39 |
| CHEMBL4854240 | — | — | 1 | 6.35 |
| CHEMBL4847328 | — | — | 1 | 6.27 |
| CHEMBL4868464 | — | — | 1 | 6.24 |
| CHEMBL4865727 | — | — | 1 | 6.19 |
| CHEMBL4875411 | — | — | 1 | 6.14 |
| CHEMBL4857682 | — | — | 1 | 6.14 |
| CHEMBL4856977 | — | — | 1 | 6.08 |
| CHEMBL4860959 | — | — | 1 | 6.03 |
| CHEMBL4848341 | — | — | 1 | 6.01 |
| CHEMBL4854516 | — | — | 1 | 6.00 |
| CHEMBL4877275 | — | — | 1 | 6.00 |
| CHEMBL4847057 | — | — | 1 | 5.94 |
| CHEMBL4854265 | — | — | 1 | 5.90 |
| CHEMBL4854823 | — | — | 1 | 5.87 |
| CHEMBL4863774 | — | — | 1 | 5.85 |
| CHEMBL4855824 | — | — | 1 | 5.77 |
| CHEMBL4854283 | — | — | 1 | 5.75 |
| CHEMBL4864991 | — | — | 1 | 5.68 |
| CHEMBL4856545 | — | — | 1 | 5.62 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 5.58 |
| CHEMBL4850983 | — | — | 1 | 5.45 |
| CHEMBL4864432 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4859691 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4864551 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4863326 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4872477 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4854462 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4875175 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4862637 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4857828 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4854240 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4847328 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4868464 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4865727 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4875411 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4857682 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4856977 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4860959 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4848341 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4854516 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4877275 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL4847057 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4854265 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL4854823 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL4863774 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL4855824 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4854283 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4864991 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL4856545 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL307261 | ARTENIMOL | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL4850983 | — | IC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL4864432 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL4849991 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4858752 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL4859809 | — | IC50 | = | 4570.0 | nM | 5.34 |
| CHEMBL4852064 | — | IC50 | = | 5890.0 | nM | 5.23 |
| CHEMBL4847197 | — | IC50 | = | 7170.0 | nM | 5.14 |
| CHEMBL4858826 | — | IC50 | = | 7170.0 | nM | 5.14 |
| CHEMBL4863130 | — | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL4857382 | — | IC50 | = | 8320.0 | nM | 5.08 |
| CHEMBL4854960 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4869209 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4857464 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4847037 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4858643 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4855715 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4863209 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4875781 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4850265 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4866393 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL428647 | PACLITAXEL | IC50 | < | 10.0 | nM | - |
| CHEMBL504767 | — | IC50 | > | 10000.0 | nM | - |