Assay Detail
Functional
CHEMBL4830278
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human PC-3 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 reagent assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Study on the structure-activity relationship of dihydroartemisinin derivatives: Discovery, synthesis, and biological evaluation of dihydroartemisinin-bile acid conjugates as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.01 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854240 | — | — | 1 | 8.00 |
| CHEMBL4859691 | — | — | 1 | 6.58 |
| CHEMBL4854960 | — | — | 1 | 6.28 |
| CHEMBL4862637 | — | — | 1 | 6.20 |
| CHEMBL4854462 | — | — | 1 | 6.11 |
| CHEMBL4877275 | — | — | 1 | 6.10 |
| CHEMBL4857828 | — | — | 1 | 6.06 |
| CHEMBL4847328 | — | — | 1 | 6.05 |
| CHEMBL4857682 | — | — | 1 | 6.01 |
| CHEMBL4849991 | — | — | 1 | 6.01 |
| CHEMBL4854823 | — | — | 1 | 5.98 |
| CHEMBL4854516 | — | — | 1 | 5.94 |
| CHEMBL4856545 | — | — | 1 | 5.86 |
| CHEMBL4875411 | — | — | 1 | 5.81 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 5.60 |
| CHEMBL4865727 | — | — | 1 | 5.55 |
| CHEMBL4847197 | — | — | 1 | 5.51 |
| CHEMBL4864991 | — | — | 1 | 5.51 |
| CHEMBL4858752 | — | — | 1 | 5.02 |
| CHEMBL4867406 | — | — | 1 | - |
| CHEMBL4847333 | — | — | 1 | - |
| CHEMBL504767 | — | — | 1 | - |
| CHEMBL4871168 | — | — | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
| CHEMBL4848313 | — | — | 1 | - |
| CHEMBL4878793 | — | — | 1 | - |
| CHEMBL4858826 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854240 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4859691 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4854960 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4862637 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4854462 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4877275 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4857828 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4847328 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4857682 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4849991 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4854823 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4854516 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL4856545 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4875411 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL307261 | ARTENIMOL | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL4865727 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL4847197 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL4864991 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL4858752 | — | IC50 | = | 9480.0 | nM | 5.02 |
| CHEMBL4867406 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4847333 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL504767 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4871168 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL428647 | PACLITAXEL | IC50 | < | 10.0 | nM | - |
| CHEMBL4848313 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4878793 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4858826 | — | IC50 | > | 10000.0 | nM | - |