Assay Detail
Functional
CHEMBL4830280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human 786-0 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 reagent assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 786-0 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Study on the structure-activity relationship of dihydroartemisinin derivatives: Discovery, synthesis, and biological evaluation of dihydroartemisinin-bile acid conjugates as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.39 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854240 | — | — | 1 | 8.00 |
| CHEMBL4854960 | — | — | 1 | 7.52 |
| CHEMBL4863326 | — | — | 1 | 7.40 |
| CHEMBL4859691 | — | — | 1 | 7.22 |
| CHEMBL4847328 | — | — | 1 | 7.22 |
| CHEMBL4857828 | — | — | 1 | 7.05 |
| CHEMBL4877275 | — | — | 1 | 7.05 |
| CHEMBL4854823 | — | — | 1 | 6.96 |
| CHEMBL4857682 | — | — | 1 | 6.89 |
| CHEMBL4854516 | — | — | 1 | 6.89 |
| CHEMBL4863130 | — | — | 1 | 6.77 |
| CHEMBL4862637 | — | — | 1 | 6.70 |
| CHEMBL4850265 | — | — | 1 | 6.50 |
| CHEMBL4875175 | — | — | 1 | 6.44 |
| CHEMBL4868464 | — | — | 1 | 6.33 |
| CHEMBL4854462 | — | — | 1 | 6.32 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 6.20 |
| CHEMBL4856545 | — | — | 1 | 6.17 |
| CHEMBL4864991 | — | — | 1 | 6.11 |
| CHEMBL4875411 | — | — | 1 | 6.01 |
| CHEMBL4864551 | — | — | 1 | 5.95 |
| CHEMBL4872477 | — | — | 1 | 5.93 |
| CHEMBL4848341 | — | — | 1 | 5.82 |
| CHEMBL4848313 | — | — | 1 | 5.78 |
| CHEMBL4849991 | — | — | 1 | 5.75 |
| CHEMBL4854265 | — | — | 1 | 5.73 |
| CHEMBL4860959 | — | — | 1 | 5.70 |
| CHEMBL4850983 | — | — | 1 | 5.62 |
| CHEMBL4858752 | — | — | 1 | 5.51 |
| CHEMBL4865727 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854240 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4854960 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4863326 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4859691 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4847328 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4857828 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4877275 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4854823 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4857682 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4854516 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4863130 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4862637 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4850265 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4875175 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4868464 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4854462 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL307261 | ARTENIMOL | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4856545 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4864991 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4875411 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4864551 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL4872477 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL4848341 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL4848313 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL4849991 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4854265 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL4860959 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4850983 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4858752 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL4865727 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4858826 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4878793 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4847333 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4847197 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4867406 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4855715 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4871168 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL504767 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL428647 | PACLITAXEL | IC50 | < | 10.0 | nM | - |