Assay Detail
Functional
CHEMBL4830282
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Anticancer activity against human NCI-H441 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 reagent assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H441 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Study on the structure-activity relationship of dihydroartemisinin derivatives: Discovery, synthesis, and biological evaluation of dihydroartemisinin-bile acid conjugates as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.03 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4859691 | — | — | 1 | 7.30 |
| CHEMBL4854240 | — | — | 1 | 7.16 |
| CHEMBL4854960 | — | — | 1 | 6.96 |
| CHEMBL4862637 | — | — | 1 | 6.92 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4859691 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4854240 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4854960 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4862637 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 150.0 | nM | 6.82 |