Assay Detail
Binding
CHEMBL4830306
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate addition
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 3a |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Hepatitis C virus serine protease, NS3/NS4A (CHEMBL2095231) ↗| Type | PROTEIN COMPLEX |
| Organism | Hepatitis C virus |
Publication
Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 52 | 8.66 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545363 | GLECAPREVIR | 4.0 | 1 | 10.30 |
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | 4.0 | 1 | 9.70 |
| CHEMBL4852970 | — | — | 1 | 9.70 |
| CHEMBL4879085 | — | — | 1 | 9.52 |
| CHEMBL4848452 | — | — | 1 | 9.30 |
| CHEMBL4854503 | — | — | 1 | 9.22 |
| CHEMBL4875061 | — | — | 1 | 9.15 |
| CHEMBL4864092 | — | — | 1 | 9.15 |
| CHEMBL4860811 | — | — | 1 | 9.05 |
| CHEMBL4863541 | — | — | 1 | 9.05 |
| CHEMBL4848772 | — | — | 1 | 9.05 |
| CHEMBL4847539 | — | — | 1 | 8.96 |
| CHEMBL4863232 | — | — | 1 | 8.96 |
| CHEMBL4846475 | — | — | 1 | 8.89 |
| CHEMBL4849669 | — | — | 1 | 8.89 |
| CHEMBL4863621 | — | — | 1 | 8.85 |
| CHEMBL4876997 | — | — | 1 | 8.82 |
| CHEMBL4852548 | — | — | 1 | 8.82 |
| CHEMBL4856675 | — | — | 1 | 8.82 |
| CHEMBL4859365 | — | — | 1 | 8.74 |
| CHEMBL4871600 | — | — | 1 | 8.74 |
| CHEMBL4866052 | — | — | 1 | 8.72 |
| CHEMBL4872547 | — | — | 1 | 8.70 |
| CHEMBL4873577 | — | — | 1 | 8.68 |
| CHEMBL4863145 | — | — | 1 | 8.68 |
| CHEMBL4847677 | — | — | 1 | 8.64 |
| CHEMBL4873756 | — | — | 1 | 8.59 |
| CHEMBL4854781 | — | — | 1 | 8.57 |
| CHEMBL4852637 | — | — | 1 | 8.55 |
| CHEMBL4861087 | — | — | 1 | 8.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545363 | GLECAPREVIR | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL4852970 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL4879085 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL4848452 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL4854503 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL4875061 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL4864092 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL4860811 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL4863541 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL4848772 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL4847539 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL4863232 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL4849669 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL4846475 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL4863621 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL4876997 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL4852548 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL4856675 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL4859365 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL4871600 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL4866052 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL4872547 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4873577 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL4863145 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL4847677 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL4873756 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL4854781 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL4852637 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL4861087 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL4848226 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL4876441 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL4873674 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL4871632 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL4870588 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL4851215 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL4875510 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4850903 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL4854266 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL4860570 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL4878695 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL4848030 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL4850597 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL4864394 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL4868136 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL4873108 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL4852913 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL4849834 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4853352 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL4875419 | — | Ki | = | 11.0 | nM | 7.96 |