Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4830308

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HCV genotype 1b infected in human Huh7 cells incubated for 96 hrs by luciferase assay
ChEMBL ↗
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Cell Type Huh-7
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗
Type ORGANISM
Organism Hepacivirus hominis

Publication

Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.
Nageswara Rao D, Zephyr J, Henes M, Chan ET, Matthew AN, Hedger AK, Conway HL, Saeed M, Newton A, Petropoulos CJ, Huang W, Kurt Yilmaz N, Schiffer CA, Ali A.
J Med Chem (2021) 64 : 11972 -11989
PubMed 34405680 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 51 9.02 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4848452 — — 1 10.00
CHEMBL4848772 — — 1 10.00
CHEMBL4863232 — — 1 10.00
CHEMBL4879085 — — 1 10.00
CHEMBL4868136 — — 1 9.70
CHEMBL3545363 GLECAPREVIR 4.0 1 9.70
CHEMBL2063090 GRAZOPREVIR ANHYDROUS 4.0 1 9.70
CHEMBL4863541 — — 1 9.70
CHEMBL4873674 — — 1 9.52
CHEMBL4849669 — — 1 9.52
CHEMBL4850903 — — 1 9.52
CHEMBL4856675 — — 1 9.52
CHEMBL4876997 — — 1 9.52
CHEMBL4852548 — — 1 9.52
CHEMBL4847677 — — 1 9.40
CHEMBL4847539 — — 1 9.30
CHEMBL4863621 — — 1 9.30
CHEMBL4866052 — — 1 9.22
CHEMBL4854503 — — 1 9.22
CHEMBL4870588 — — 1 9.22
CHEMBL4878695 — — 1 9.15
CHEMBL4864092 — — 1 9.10
CHEMBL4873756 — — 1 9.10
CHEMBL4875061 — — 1 9.10
CHEMBL4850597 — — 1 9.05
CHEMBL4848030 — — 1 9.05
CHEMBL4851215 — — 1 9.00
CHEMBL4871632 — — 1 8.92
CHEMBL4872547 — — 1 8.85
CHEMBL4854781 — — 1 8.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4848452 — EC50 = 0.1 nM 10.00
CHEMBL4879085 — EC50 = 0.1 nM 10.00
CHEMBL4863232 — EC50 = 0.1 nM 10.00
CHEMBL4848772 — EC50 = 0.1 nM 10.00
CHEMBL4868136 — EC50 = 0.2 nM 9.70
CHEMBL3545363 GLECAPREVIR EC50 = 0.2 nM 9.70
CHEMBL2063090 GRAZOPREVIR ANHYDROUS EC50 = 0.2 nM 9.70
CHEMBL4863541 — EC50 = 0.2 nM 9.70
CHEMBL4873674 — EC50 = 0.3 nM 9.52
CHEMBL4849669 — EC50 = 0.3 nM 9.52
CHEMBL4850903 — EC50 = 0.3 nM 9.52
CHEMBL4856675 — EC50 = 0.3 nM 9.52
CHEMBL4876997 — EC50 = 0.3 nM 9.52
CHEMBL4852548 — EC50 = 0.3 nM 9.52
CHEMBL4847677 — EC50 = 0.4 nM 9.40
CHEMBL4847539 — EC50 = 0.5 nM 9.30
CHEMBL4863621 — EC50 = 0.5 nM 9.30
CHEMBL4866052 — EC50 = 0.6 nM 9.22
CHEMBL4854503 — EC50 = 0.6 nM 9.22
CHEMBL4870588 — EC50 = 0.6 nM 9.22
CHEMBL4878695 — EC50 = 0.7 nM 9.15
CHEMBL4864092 — EC50 = 0.8 nM 9.10
CHEMBL4873756 — EC50 = 0.8 nM 9.10
CHEMBL4875061 — EC50 = 0.8 nM 9.10
CHEMBL4848030 — EC50 = 0.9 nM 9.05
CHEMBL4850597 — EC50 = 0.9 nM 9.05
CHEMBL4851215 — EC50 = 1.0 nM 9.00
CHEMBL4871632 — EC50 = 1.2 nM 8.92
CHEMBL4872547 — EC50 = 1.4 nM 8.85
CHEMBL4854781 — EC50 = 1.5 nM 8.82
CHEMBL4846475 — EC50 = 1.6 nM 8.80
CHEMBL4860570 — EC50 = 1.6 nM 8.80
CHEMBL4852637 — EC50 = 1.6 nM 8.80
CHEMBL4852913 — EC50 = 1.8 nM 8.74
CHEMBL4876702 — EC50 = 2.0 nM 8.70
CHEMBL4876441 — EC50 = 2.1 nM 8.68
CHEMBL4859750 — EC50 = 2.6 nM 8.59
CHEMBL4873577 — EC50 = 2.7 nM 8.57
CHEMBL4852970 — EC50 = 3.0 nM 8.52
CHEMBL4875419 — EC50 = 3.2 nM 8.49
CHEMBL4873108 — EC50 = 3.2 nM 8.49
CHEMBL4849834 — EC50 = 3.3 nM 8.48
CHEMBL4859365 — EC50 = 3.7 nM 8.43
CHEMBL4854266 — EC50 = 4.1 nM 8.39
CHEMBL4875510 — EC50 = 4.8 nM 8.32
CHEMBL4861087 — EC50 = 4.9 nM 8.31
CHEMBL4871600 — EC50 = 5.3 nM 8.28
CHEMBL4864394 — EC50 = 5.6 nM 8.25
CHEMBL4860811 — EC50 = 5.8 nM 8.24
CHEMBL4848226 — EC50 = 5.7 nM 8.24