Assay Detail
Functional
CHEMBL4830309
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV genotype 1b harboring A156T mutant infected in human Huh7 cells incubated for 96 hrs by luciferase assay
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 51 | 7.72 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4870588 | — | — | 1 | 8.68 |
| CHEMBL4863232 | — | — | 1 | 8.54 |
| CHEMBL4873756 | — | — | 1 | 8.48 |
| CHEMBL4879085 | — | — | 1 | 8.47 |
| CHEMBL4863621 | — | — | 1 | 8.38 |
| CHEMBL4872547 | — | — | 1 | 8.29 |
| CHEMBL4854503 | — | — | 1 | 8.28 |
| CHEMBL4848452 | — | — | 1 | 8.28 |
| CHEMBL4848772 | — | — | 1 | 8.25 |
| CHEMBL4856675 | — | — | 1 | 8.23 |
| CHEMBL4849669 | — | — | 1 | 8.21 |
| CHEMBL4863541 | — | — | 1 | 8.17 |
| CHEMBL4866052 | — | — | 1 | 8.15 |
| CHEMBL4852548 | — | — | 1 | 8.11 |
| CHEMBL4864092 | — | — | 1 | 8.09 |
| CHEMBL4846475 | — | — | 1 | 8.08 |
| CHEMBL4873674 | — | — | 1 | 8.08 |
| CHEMBL4875061 | — | — | 1 | 8.07 |
| CHEMBL4850597 | — | — | 1 | 8.06 |
| CHEMBL4852913 | — | — | 1 | 8.02 |
| CHEMBL4851215 | — | — | 1 | 8.00 |
| CHEMBL4854781 | — | — | 1 | 8.00 |
| CHEMBL4876997 | — | — | 1 | 7.96 |
| CHEMBL4848030 | — | — | 1 | 7.92 |
| CHEMBL4847677 | — | — | 1 | 7.92 |
| CHEMBL4850903 | — | — | 1 | 7.92 |
| CHEMBL4849834 | — | — | 1 | 7.75 |
| CHEMBL4847539 | — | — | 1 | 7.75 |
| CHEMBL4878695 | — | — | 1 | 7.72 |
| CHEMBL4860570 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4870588 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4863232 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4873756 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4879085 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4863621 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4872547 | — | EC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4854503 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4848452 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4848772 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4856675 | — | EC50 | = | 5.9 | nM | 8.23 |
| CHEMBL4849669 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4863541 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL4866052 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4852548 | — | EC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4864092 | — | EC50 | = | 8.1 | nM | 8.09 |
| CHEMBL4846475 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL4873674 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL4875061 | — | EC50 | = | 8.5 | nM | 8.07 |
| CHEMBL4850597 | — | EC50 | = | 8.7 | nM | 8.06 |
| CHEMBL4852913 | — | EC50 | = | 9.6 | nM | 8.02 |
| CHEMBL4851215 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4854781 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4876997 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4850903 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4848030 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4847677 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4849834 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4847539 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4878695 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4860570 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4852637 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4875419 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4868136 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4876702 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4848226 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4871632 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4859750 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4876441 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4873108 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4859365 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4852970 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4860811 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4864394 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4854266 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4875510 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL4853352 | — | EC50 | = | 99.0 | nM | 7.00 |
| CHEMBL4873577 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4871600 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL4861087 | — | EC50 | = | 158.0 | nM | 6.80 |
| CHEMBL3545363 | GLECAPREVIR | EC50 | = | 230.0 | nM | 6.64 |