Assay Detail
Functional
CHEMBL4830327
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549/TR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.44 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4855608 | — | — | 1 | 8.55 |
| CHEMBL4871913 | — | — | 1 | 8.27 |
| CHEMBL4876313 | — | — | 1 | 8.09 |
| CHEMBL4857102 | — | — | 1 | 7.68 |
| CHEMBL4849437 | — | — | 1 | 7.51 |
| CHEMBL4876166 | — | — | 1 | 7.33 |
| CHEMBL4863678 | — | — | 1 | 7.28 |
| CHEMBL4850900 | — | — | 1 | 7.18 |
| CHEMBL4879163 | — | — | 1 | 6.85 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.69 |
| CHEMBL4858577 | — | — | 1 | 6.40 |
| CHEMBL4878879 | — | — | 1 | - |
| CHEMBL4855607 | — | — | 1 | - |
| CHEMBL4864654 | — | — | 1 | - |
| CHEMBL4845756 | — | — | 1 | - |
| CHEMBL4878065 | — | — | 1 | - |
| CHEMBL4059730 | — | — | 1 | - |
| CHEMBL4088019 | — | — | 1 | - |
| CHEMBL4075372 | — | — | 1 | - |
| CHEMBL4861176 | — | — | 1 | - |
| CHEMBL4877188 | — | — | 1 | - |
| CHEMBL4859195 | — | — | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
| CHEMBL4520878 | — | — | 1 | - |
| CHEMBL492399 | VERUBULIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4855608 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4871913 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4876313 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL4857102 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4849437 | — | IC50 | = | 30.6 | nM | 7.51 |
| CHEMBL4876166 | — | IC50 | = | 47.3 | nM | 7.33 |
| CHEMBL4863678 | — | IC50 | = | 52.6 | nM | 7.28 |
| CHEMBL4850900 | — | IC50 | = | 65.8 | nM | 7.18 |
| CHEMBL4879163 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL107 | COLCHICINE | IC50 | = | 202.9 | nM | 6.69 |
| CHEMBL4858577 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL4878879 | — | IC50 | - | — | - | |
| CHEMBL4855607 | — | IC50 | - | — | - | |
| CHEMBL4864654 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4845756 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4878065 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4059730 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4088019 | — | IC50 | - | — | - | |
| CHEMBL4075372 | — | IC50 | - | — | - | |
| CHEMBL4861176 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4877188 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4859195 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL428647 | PACLITAXEL | IC50 | > | 1000.0 | nM | - |
| CHEMBL4520878 | — | IC50 | - | — | - | |
| CHEMBL492399 | VERUBULIN | IC50 | - | — | - |