Assay Detail
Functional
CHEMBL4830385
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Antiproliferative activity against human A375/TxR cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A375/TxR |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.32 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492399 | VERUBULIN | 2.0 | 1 | 9.15 |
| CHEMBL4855608 | — | — | 1 | 8.96 |
| CHEMBL4871913 | — | — | 1 | 8.89 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.63 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492399 | VERUBULIN | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4855608 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4871913 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL107 | COLCHICINE | IC50 | = | 23.6 | nM | 7.63 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 103.8 | nM | 6.98 |