Assay Detail
Functional
CHEMBL4830552
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of pyridinylmethylenepiperidine derivatives as potent 5-HT<sub>1F</sub> receptor agonists for migraine therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.27 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4847626 | — | — | 1 | 8.33 |
| CHEMBL4846825 | — | — | 1 | 8.20 |
| CHEMBL4851044 | — | — | 1 | 7.71 |
| CHEMBL4865700 | — | — | 1 | 7.63 |
| CHEMBL4860576 | — | — | 1 | 7.61 |
| CHEMBL4862526 | — | — | 1 | 7.53 |
| CHEMBL3039520 | LASMIDITAN | 4.0 | 1 | 7.06 |
| CHEMBL4852743 | — | — | 1 | 6.79 |
| CHEMBL4874958 | — | — | 1 | 6.75 |
| CHEMBL4872571 | — | — | 1 | 6.24 |
| CHEMBL4871295 | — | — | 1 | 6.09 |
| CHEMBL4861949 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4847626 | — | IC50 | = | 4.67 | nM | 8.33 |
| CHEMBL4846825 | — | IC50 | = | 6.36 | nM | 8.20 |
| CHEMBL4851044 | — | IC50 | = | 19.55 | nM | 7.71 |
| CHEMBL4865700 | — | IC50 | = | 23.41 | nM | 7.63 |
| CHEMBL4860576 | — | IC50 | = | 24.32 | nM | 7.61 |
| CHEMBL4862526 | — | IC50 | = | 29.35 | nM | 7.53 |
| CHEMBL3039520 | LASMIDITAN | IC50 | = | 87.84 | nM | 7.06 |
| CHEMBL4852743 | — | IC50 | = | 160.9 | nM | 6.79 |
| CHEMBL4874958 | — | IC50 | = | 178.05 | nM | 6.75 |
| CHEMBL4872571 | — | IC50 | = | 570.5 | nM | 6.24 |
| CHEMBL4871295 | — | IC50 | = | 813.4 | nM | 6.09 |
| CHEMBL4861949 | — | IC50 | > | 10000.0 | nM | - |