Assay Detail
Functional
CHEMBL4830600
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Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocyte assessed as intraerythrocytic growth inhibition incubated for 72 hrs by DAPI-staining based imaging analysis
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 6.24 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 9.22 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 8.22 |
| CHEMBL4874145 | — | — | 1 | 7.60 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.55 |
| CHEMBL4857536 | — | — | 1 | 7.27 |
| CHEMBL4846372 | — | — | 1 | 7.14 |
| CHEMBL4846579 | — | — | 1 | 6.80 |
| CHEMBL4859763 | — | — | 1 | 6.75 |
| CHEMBL4862256 | — | — | 1 | 6.55 |
| CHEMBL4871489 | — | — | 1 | 6.51 |
| CHEMBL4852040 | — | — | 1 | 6.39 |
| CHEMBL4857901 | — | — | 1 | 6.38 |
| CHEMBL4872525 | — | — | 1 | 6.26 |
| CHEMBL4859817 | — | — | 1 | 6.23 |
| CHEMBL4866642 | — | — | 1 | 6.05 |
| CHEMBL4853205 | — | — | 1 | 5.94 |
| CHEMBL4854656 | — | — | 1 | 5.94 |
| CHEMBL4858796 | — | — | 1 | 5.94 |
| CHEMBL4859826 | — | — | 1 | 5.80 |
| CHEMBL4850316 | — | — | 1 | 5.79 |
| CHEMBL4857112 | — | — | 1 | 5.78 |
| CHEMBL4846590 | — | — | 1 | 5.72 |
| CHEMBL4857049 | — | — | 1 | 5.72 |
| CHEMBL3359091 | — | — | 1 | 5.62 |
| CHEMBL4875826 | — | — | 1 | 5.50 |
| CHEMBL4876537 | — | — | 1 | 5.43 |
| CHEMBL4846594 | — | — | 1 | 5.35 |
| CHEMBL4856504 | — | — | 1 | 5.32 |
| CHEMBL4858445 | — | — | 1 | 5.29 |
| CHEMBL4868499 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4874145 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4857536 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4846372 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4846579 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4859763 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4862256 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4871489 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4852040 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4857901 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4872525 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4859817 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4866642 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4853205 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL4858796 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4854656 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL4859826 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL4850316 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL4857112 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4846590 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4857049 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL3359091 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL4875826 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL4876537 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL4846594 | — | IC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL4856504 | — | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL4858445 | — | IC50 | = | 5130.0 | nM | 5.29 |
| CHEMBL4868499 | — | IC50 | = | 5540.0 | nM | 5.26 |
| CHEMBL4858666 | — | IC50 | = | 5940.0 | nM | 5.23 |
| CHEMBL4871069 | — | IC50 | = | 6970.0 | nM | 5.16 |
| CHEMBL3359088 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3359090 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4856967 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4859040 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4864167 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4873366 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4854003 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4855410 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4857192 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4868180 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4865937 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4861451 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4856624 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4856479 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4848733 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL269671 | ARTEMISININ | IC50 | - | — | - | |
| CHEMBL1450 | ATOVAQUONE | IC50 | - | — | - |