Assay Detail
Functional
CHEMBL4830669
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Antiproliferative activity against human RPMI 8226 cells assessed as reduction in cell viability incubated for 72 hrs by XTT assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Activity Relationships of Withanolides as Antiproliferative Agents for Multiple Myeloma: Comparison of Activity in 2D Models and a 3D Coculture Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.51 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.33 |
| CHEMBL4288984 | WITHANOLIDE D | 3.0 | 1 | 7.12 |
| CHEMBL4857813 | — | — | 1 | 6.98 |
| CHEMBL4852942 | — | — | 1 | 6.91 |
| CHEMBL4850374 | — | — | 1 | 6.75 |
| CHEMBL3234472 | — | — | 1 | 6.73 |
| CHEMBL3234471 | — | — | 1 | 6.69 |
| CHEMBL2047407 | — | — | 1 | 6.67 |
| CHEMBL469945 | — | — | 1 | 6.66 |
| CHEMBL4869263 | — | — | 1 | 6.66 |
| CHEMBL4846709 | — | — | 1 | 6.66 |
| CHEMBL4870538 | — | — | 1 | 6.62 |
| CHEMBL4847060 | — | — | 1 | 6.61 |
| CHEMBL4864258 | — | — | 1 | 6.60 |
| CHEMBL4848017 | — | — | 1 | 6.60 |
| CHEMBL517080 | WITHAFERIN A | 1.0 | 1 | 6.59 |
| CHEMBL4869516 | — | — | 1 | 6.57 |
| CHEMBL4282914 | — | — | 1 | 6.56 |
| CHEMBL452952 | WITHAPHYSACARPIN | — | 1 | 6.56 |
| CHEMBL4849546 | — | — | 1 | 6.53 |
| CHEMBL4859862 | — | — | 1 | 6.52 |
| CHEMBL4864781 | — | — | 1 | 6.35 |
| CHEMBL4846956 | — | — | 1 | 6.34 |
| CHEMBL4851958 | — | — | 1 | 6.32 |
| CHEMBL4855317 | — | — | 1 | 6.30 |
| CHEMBL4863163 | — | — | 1 | 6.26 |
| CHEMBL4871909 | — | — | 1 | 6.22 |
| CHEMBL4867721 | — | — | 1 | 6.21 |
| CHEMBL4845776 | — | — | 1 | 6.20 |
| CHEMBL4852605 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4288984 | WITHANOLIDE D | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4857813 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4852942 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL4850374 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL3234472 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL3234471 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL2047407 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL469945 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL4869263 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL4846709 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL4870538 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL4847060 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL4864258 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL4848017 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL517080 | WITHAFERIN A | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL4869516 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL452952 | WITHAPHYSACARPIN | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL4282914 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL4849546 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL4859862 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL4864781 | — | IC50 | = | 451.0 | nM | 6.35 |
| CHEMBL4846956 | — | IC50 | = | 458.0 | nM | 6.34 |
| CHEMBL4851958 | — | IC50 | = | 484.0 | nM | 6.32 |
| CHEMBL4855317 | — | IC50 | = | 506.0 | nM | 6.30 |
| CHEMBL4863163 | — | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL4871909 | — | IC50 | = | 601.0 | nM | 6.22 |
| CHEMBL4867721 | — | IC50 | = | 609.0 | nM | 6.21 |
| CHEMBL4845776 | — | IC50 | = | 632.0 | nM | 6.20 |
| CHEMBL4852605 | — | IC50 | = | 744.0 | nM | 6.13 |
| CHEMBL4871698 | — | IC50 | = | 768.0 | nM | 6.12 |
| CHEMBL4855054 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4858869 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL3234486 | — | IC50 | = | 777.0 | nM | 6.11 |
| CHEMBL4290783 | — | IC50 | = | 889.0 | nM | 6.05 |
| CHEMBL4852603 | — | IC50 | = | 942.0 | nM | 6.03 |
| CHEMBL4857213 | — | IC50 | = | 950.0 | nM | 6.02 |