Assay Detail
Binding
CHEMBL4830671
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNF-alpha stimulated NF-KappaB in human HEK293 cells transfected with NF-kappaB-Luc incubated for 5 hrs by luciferase reporter gene assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Nuclear factor NF-kappa-B complex (CHEMBL2094258) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Structure-Activity Relationships of Withanolides as Antiproliferative Agents for Multiple Myeloma: Comparison of Activity in 2D Models and a 3D Coculture Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.82 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4850374 | — | — | 1 | 7.82 |
| CHEMBL4848017 | — | — | 1 | 7.50 |
| CHEMBL4288984 | WITHANOLIDE D | 3.0 | 1 | 7.44 |
| CHEMBL4852942 | — | — | 1 | 7.39 |
| CHEMBL517080 | WITHAFERIN A | 1.0 | 1 | 7.33 |
| CHEMBL4869263 | — | — | 1 | 7.30 |
| CHEMBL3234472 | — | — | 1 | 7.26 |
| CHEMBL3234471 | — | — | 1 | 7.25 |
| CHEMBL4859862 | — | — | 1 | 7.23 |
| CHEMBL4857813 | — | — | 1 | 7.20 |
| CHEMBL2047407 | — | — | 1 | 7.16 |
| CHEMBL4849546 | — | — | 1 | 7.15 |
| CHEMBL452952 | WITHAPHYSACARPIN | — | 1 | 7.13 |
| CHEMBL4864258 | — | — | 1 | 7.10 |
| CHEMBL4870538 | — | — | 1 | 7.02 |
| CHEMBL4846956 | — | — | 1 | 7.02 |
| CHEMBL4846709 | — | — | 1 | 6.99 |
| CHEMBL4847060 | — | — | 1 | 6.90 |
| CHEMBL4855317 | — | — | 1 | 6.88 |
| CHEMBL4852605 | — | — | 1 | 6.84 |
| CHEMBL4851958 | — | — | 1 | 6.68 |
| CHEMBL4871698 | — | — | 1 | 6.68 |
| CHEMBL4869516 | — | — | 1 | 6.66 |
| CHEMBL4855054 | — | — | 1 | 6.61 |
| CHEMBL4857213 | — | — | 1 | 6.58 |
| CHEMBL4867721 | — | — | 1 | 6.56 |
| CHEMBL4863163 | — | — | 1 | 6.48 |
| CHEMBL4298697 | — | — | 1 | 6.33 |
| CHEMBL4871909 | — | — | 1 | 6.32 |
| CHEMBL4282914 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4850374 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4848017 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4288984 | WITHANOLIDE D | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4852942 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL517080 | WITHAFERIN A | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4869263 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3234472 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3234471 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4859862 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4857813 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL2047407 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4849546 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL452952 | WITHAPHYSACARPIN | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4864258 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4846956 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4870538 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4846709 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL4847060 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL4855317 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL4852605 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL4851958 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL4871698 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL4869516 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4855054 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL4857213 | — | IC50 | = | 261.0 | nM | 6.58 |
| CHEMBL4867721 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL4863163 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL4298697 | — | IC50 | = | 467.0 | nM | 6.33 |
| CHEMBL4871909 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4282914 | — | IC50 | = | 493.0 | nM | 6.31 |
| CHEMBL4861753 | — | IC50 | = | 841.0 | nM | 6.08 |
| CHEMBL469945 | — | IC50 | = | 913.0 | nM | 6.04 |
| CHEMBL4852603 | — | IC50 | = | 1075.0 | nM | 5.97 |
| CHEMBL4864781 | — | IC50 | = | 2093.0 | nM | 5.68 |
| CHEMBL4854305 | — | IC50 | = | 2093.0 | nM | 5.68 |