Assay Detail
Functional
CHEMBL4830752
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Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition after 72 hrs by SRB assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MGC-803 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel tubulin/HDAC dual-targeting inhibitors with strong antitumor and antiangiogenic potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.63 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.70 |
| CHEMBL4849152 | — | — | 1 | 7.89 |
| CHEMBL4874942 | — | — | 1 | 7.80 |
| CHEMBL4853727 | — | — | 1 | 7.20 |
| CHEMBL4854066 | — | — | 1 | 6.98 |
| CHEMBL4851894 | — | — | 1 | 6.84 |
| CHEMBL4865690 | — | — | 1 | 6.74 |
| CHEMBL4863938 | — | — | 1 | 6.68 |
| CHEMBL4849829 | — | — | 1 | 6.52 |
| CHEMBL4870515 | — | — | 1 | 6.22 |
| CHEMBL4852344 | — | — | 1 | 6.03 |
| CHEMBL4864836 | — | — | 1 | 5.96 |
| CHEMBL4846570 | — | — | 1 | 5.96 |
| CHEMBL4860227 | — | — | 1 | 5.95 |
| CHEMBL4858636 | — | — | 1 | 5.89 |
| CHEMBL4871135 | — | — | 1 | 5.79 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.57 |
| CHEMBL4878526 | — | — | 1 | - |
| CHEMBL4877927 | — | — | 1 | - |
| CHEMBL4866922 | — | — | 1 | - |
| CHEMBL4868798 | — | — | 1 | - |
| CHEMBL4877702 | — | — | 1 | - |
| CHEMBL4876859 | — | — | 1 | - |
| CHEMBL4866745 | — | — | 1 | - |
| CHEMBL4858547 | — | — | 1 | - |
| CHEMBL4849728 | — | — | 1 | - |
| CHEMBL4856739 | — | — | 1 | - |
| CHEMBL4878294 | — | — | 1 | - |
| CHEMBL4850912 | — | — | 1 | - |
| CHEMBL4873916 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4849152 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4874942 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4853727 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4854066 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL4851894 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL4865690 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL4863938 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL4849829 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL4870515 | — | IC50 | = | 604.0 | nM | 6.22 |
| CHEMBL4852344 | — | IC50 | = | 927.0 | nM | 6.03 |
| CHEMBL4846570 | — | IC50 | = | 1093.0 | nM | 5.96 |
| CHEMBL4864836 | — | IC50 | = | 1103.0 | nM | 5.96 |
| CHEMBL4860227 | — | IC50 | = | 1131.0 | nM | 5.95 |
| CHEMBL4858636 | — | IC50 | = | 1293.0 | nM | 5.89 |
| CHEMBL4871135 | — | IC50 | = | 1614.0 | nM | 5.79 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2678.0 | nM | 5.57 |
| CHEMBL4862093 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4862819 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4848320 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4877365 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4873916 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4850912 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4878294 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4856739 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4849728 | — | IC50 | = | 1364000.0 | nM | - |
| CHEMBL4858547 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4866745 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4876859 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4877702 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4868798 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4866922 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4877927 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4878526 | — | IC50 | > | 5000.0 | nM | - |