Assay Detail
Functional
CHEMBL4830753
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by SRB assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel tubulin/HDAC dual-targeting inhibitors with strong antitumor and antiangiogenic potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.24 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.15 |
| CHEMBL4874942 | — | — | 1 | 7.58 |
| CHEMBL4853727 | — | — | 1 | 7.09 |
| CHEMBL4849152 | — | — | 1 | 6.91 |
| CHEMBL4851894 | — | — | 1 | 6.79 |
| CHEMBL4863938 | — | — | 1 | 6.60 |
| CHEMBL4854066 | — | — | 1 | 6.28 |
| CHEMBL4864836 | — | — | 1 | 5.93 |
| CHEMBL4871135 | — | — | 1 | 5.81 |
| CHEMBL4849829 | — | — | 1 | 5.56 |
| CHEMBL4870515 | — | — | 1 | 5.47 |
| CHEMBL4860227 | — | — | 1 | 5.45 |
| CHEMBL4852344 | — | — | 1 | 5.34 |
| CHEMBL4849728 | — | — | 1 | 5.33 |
| CHEMBL4858636 | — | — | 1 | 5.31 |
| CHEMBL4877365 | — | — | 1 | - |
| CHEMBL4873916 | — | — | 1 | - |
| CHEMBL4850912 | — | — | 1 | - |
| CHEMBL4878294 | — | — | 1 | - |
| CHEMBL4865690 | — | — | 1 | - |
| CHEMBL4862093 | — | — | 1 | - |
| CHEMBL4856739 | — | — | 1 | - |
| CHEMBL4858547 | — | — | 1 | - |
| CHEMBL4866745 | — | — | 1 | - |
| CHEMBL4876859 | — | — | 1 | - |
| CHEMBL4877702 | — | — | 1 | - |
| CHEMBL4868798 | — | — | 1 | - |
| CHEMBL4866922 | — | — | 1 | - |
| CHEMBL4878526 | — | — | 1 | - |
| CHEMBL4846570 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4874942 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4853727 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4849152 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL4851894 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL4863938 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL4854066 | — | IC50 | = | 521.0 | nM | 6.28 |
| CHEMBL4864836 | — | IC50 | = | 1165.0 | nM | 5.93 |
| CHEMBL4871135 | — | IC50 | = | 1557.0 | nM | 5.81 |
| CHEMBL4849829 | — | IC50 | = | 2757.0 | nM | 5.56 |
| CHEMBL4870515 | — | IC50 | = | 3411.0 | nM | 5.47 |
| CHEMBL4860227 | — | IC50 | = | 3556.0 | nM | 5.45 |
| CHEMBL4852344 | — | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL4849728 | — | IC50 | = | 4696.0 | nM | 5.33 |
| CHEMBL4858636 | — | IC50 | = | 4919.0 | nM | 5.31 |
| CHEMBL4862819 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4877927 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3385000.0 | nM | - |
| CHEMBL4848320 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4877365 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4873916 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4850912 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4878294 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4865690 | — | IC50 | = | 1328000.0 | nM | - |
| CHEMBL4862093 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4856739 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4858547 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4866745 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4876859 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4877702 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4868798 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4866922 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4878526 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4846570 | — | IC50 | > | 5000.0 | nM | - |