Assay Detail
Binding
CHEMBL4830762
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Inhibition of HDAC (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of novel tubulin/HDAC dual-targeting inhibitors with strong antitumor and antiangiogenic potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.39 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.72 |
| CHEMBL4854066 | — | — | 1 | 6.60 |
| CHEMBL4865690 | — | — | 1 | 6.41 |
| CHEMBL4874942 | — | — | 1 | 6.37 |
| CHEMBL4853727 | — | — | 1 | 5.85 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4854066 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4865690 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4874942 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4853727 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | - | — | - |