Assay Detail
Functional
CHEMBL4831083
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Cytotoxicity against human NCI-H1299 cells assessed as cell viability measured after 96 hrs by XTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeted methylation facilitates DNA double strand breaks and enhances cancer suppression: A DNA intercalating/methylating dual-action chimera Amonafidazene.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.41 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4866726 | — | — | 1 | 5.75 |
| CHEMBL4871205 | — | — | 1 | 5.44 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.05 |
| CHEMBL4872645 | — | — | 1 | - |
| CHEMBL810 | TEMOZOLOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4866726 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL4871205 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 8840.0 | nM | 5.05 |
| CHEMBL4872645 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL810 | TEMOZOLOMIDE | IC50 | > | 100000.0 | nM | - |