Assay Detail
Functional
CHEMBL4831084
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MDA-MB-238 cells assessed as cell viability measured after 96 hrs by XTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-238 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeted methylation facilitates DNA double strand breaks and enhances cancer suppression: A DNA intercalating/methylating dual-action chimera Amonafidazene.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.11 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4866726 | — | — | 1 | 5.52 |
| CHEMBL4871205 | — | — | 1 | 5.20 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 4.62 |
| CHEMBL4872645 | — | — | 1 | - |
| CHEMBL810 | TEMOZOLOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4866726 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL4871205 | — | IC50 | = | 6260.0 | nM | 5.20 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 24250.0 | nM | 4.62 |
| CHEMBL4872645 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL810 | TEMOZOLOMIDE | IC50 | > | 100000.0 | nM | - |