Assay Detail
Functional
CHEMBL4831463
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Acremopeptaibols A-F, 16-Residue Peptaibols from the Sponge-Derived <i>Acremonium</i> sp. IMB18-086 Cultivated with Heat-Killed <i>Pseudomonas aeruginosa</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.05 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL132623 | ASCOCHLORIN | — | 1 | 6.05 |
| CHEMBL4846724 | — | — | 1 | 6.05 |
| CHEMBL4852487 | — | — | 1 | 6.05 |
| CHEMBL133046 | ASCOFURANONE | — | 1 | 6.05 |
| CHEMBL4853583 | — | — | 1 | - |
| CHEMBL4873334 | — | — | 1 | - |
| CHEMBL4865863 | — | — | 1 | - |
| CHEMBL4874282 | — | — | 1 | - |
| CHEMBL4851840 | — | — | 1 | - |
| CHEMBL4872052 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL132623 | ASCOCHLORIN | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4846724 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4852487 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL133046 | ASCOFURANONE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4853583 | — | IC50 | >= | 50000.0 | nM | - |
| CHEMBL4873334 | — | IC50 | >= | 50000.0 | nM | - |
| CHEMBL4865863 | — | IC50 | >= | 50000.0 | nM | - |
| CHEMBL4874282 | — | IC50 | >= | 50000.0 | nM | - |
| CHEMBL4851840 | — | IC50 | >= | 50000.0 | nM | - |
| CHEMBL4872052 | — | IC50 | >= | 50000.0 | nM | - |