Assay Detail
Binding
CHEMBL4831907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse Panx-1 expressed in Xenopus laevis oocytes assessed as inhibition of membrane current cells held at -60 mV and voltage steps to +60 mV in presence of CBX measured by Whole cell voltage clamp assay relative to control
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of the first indole-based blockers of Panx-1 channel.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.33 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4855581 | — | — | 1 | 6.60 |
| CHEMBL3184128 | — | — | 1 | 6.57 |
| CHEMBL4847247 | — | — | 1 | 6.10 |
| CHEMBL4858078 | — | — | 1 | 5.31 |
| CHEMBL499915 | CARBENOXOLONE | 2.0 | 1 | 5.00 |
| CHEMBL4862099 | — | — | 1 | 4.91 |
| CHEMBL4849404 | — | — | 1 | 4.64 |
| CHEMBL4873114 | — | — | 1 | 4.56 |
| CHEMBL1256759 | 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC ACID [NPPB] | — | 1 | 4.30 |
| CHEMBL897 | PROBENECID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4855581 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3184128 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4847247 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4858078 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL499915 | CARBENOXOLONE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4862099 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4849404 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL4873114 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL1256759 | 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC ACID [NPPB] | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL897 | PROBENECID | IC50 | = | 150000.0 | nM | - |