Assay Detail
Functional
CHEMBL4832180
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Antiproliferative activity against human HT-29 cells assessed as inhibition of cell viability for 96 hrs by cell titre glo luminescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.22 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4866490 | — | — | 1 | 5.60 |
| CHEMBL4282040 | — | — | 1 | 5.16 |
| CHEMBL4870906 | — | — | 1 | 5.08 |
| CHEMBL4852896 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4866490 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4282040 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4870906 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4852896 | — | IC50 | = | 9000.0 | nM | 5.05 |